发给老马备查:
7 B1 s0 q4 O8 X0 v2 n( I滴水察海(69304838) 15:23:232 T1 e; z7 K" @/ o
老马,我看到培美和S-1都提到TS低表达,而鳞多半不是低表达,是不是S-1不靠谱
- K s" u( J' j. q3 } H7 B" x吉非替尼和S-1连用的依据
! U5 p6 d% ]& W1 z: `Gefitinib induced down-regulation of thymidylate synthase and E2F-1 in gefitinib-resistant NSCLC cells with MET amplification but not in those harboring the T790M mutation of EGFR. The combination of 5-fluorouracil and gefitinib synergistically inhibited the proliferation of cells with MET amplification, but not that of those with the T790M mutation of EGFR, in vitro.- j+ n" J4 Y* Z4 H9 Y& R0 q3 R( F
是不是说因C-MET引起的耐药中,吉非替尼会引导TS低表达
+ F9 [- W. b2 n z+ E/ }6 t这样是不是推理出,耐药后,可以用S-1和培美了?' H1 Q: m& \) B
结论:
% t8 Z N7 M, W, a如果是T790M突变引起的耐药,则2992有效,如果是C-MET扩增引起的突变,则除了184,还可以特+S1联用,而且可能可以用培美。 |