IL-2联褪黑素化疗后维持治疗结肠癌的，比没有维持治疗的提高了一年生存率，部分病人维持治疗时肿瘤继续退缩。
http://www.ncbi.nlm.nih.gov/pubmed/7715908
A randomized study of low-dose subcutaneous interleukin-2 plus melatonin versus supportive care alone in metastatic colorectal cancer patients progressing under 5-fluorouracil and folates.
Abstract
Chemotherapy with 5-fluorouracil (5-FU) and folates represents the first-line standard therapy for metastatic colorectal cancer, whereas at present there is no conventional second-time treatment. Because of its importance in generating an effective anticancer immune response, interleukin-2 (IL-2) could constitute a new promising therapy of advanced colon cancer. Generally, IL-2 may determine tumor regressions in colon cancer only when it is given at high toxic doses. Our preliminary studies have shown that the pineal hormone melatonin may amplify IL-2 activity, which becomes active also at low doses in several tumor histotypes. On the basis, we have performed a clinical trial to evaluate the impact of low-dose IL-2 plus melatonin on the survival time in metastatic colon cancer, which progressed in response to 5-FU plus folates. The study included 50 metastatic colorectal cancer patients, who did not respond or progressed after initial response to first-line chemotherapy with 5-FU and folates. Patients were randomized to receive supportive care alone or low-dose subcutaneous IL-2 (3 million IU/day for 6 days/week for 4 weeks) plus melatonin (40 mg/day orally). No spontaneous tumor regression occurred in patients receiving supportive care alone. A partial response was achieved in 3/25 patients treated with immunotherapy. Percent survival at 1 year was significantly higher in patients treated with immunotherapy than in those treated with supportive care alone (9/25 vs. 3/25, p < 0.05). This study suggests that low-dose subcutaneous IL-2 plus melatonin may be effective as a second-line therapy to induce tumor regression and to prolong percent survival at 1 year in metastatic colorectal cancer patients progressing under 5-FU and folates.
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肺腺癌晚期ⅣB，基因靶点KARS-G12C，
各位老师，我哥肺腺癌晚期，患有强直性脊柱炎，目前治疗方案为：贝伐单抗＋化疗药，10
中国首个KRAS G12C抑制剂-达伯特®（
国家药品监督管理局批准氟泽雷塞上市
好消息！2024年8月21日，信达生物制药的KRAS G12
卧床肿瘤患者最常见的2个并发症，及
作者：小莱
“病来如山倒，病去如抽丝”，卧床静养一直以来被视为疗愈疾病中的重要一
父亲的治疗传来了好消息
父亲今年68岁，从今年三月低确认肺癌晚期到现在，一直没有好消息。胸水基因检测：EGFR
无奈，崩溃，不知所措
我父亲2月份确诊鳞T2N3M0，后4次化免后的28次放疗，7月底放疗结束复查左肺还有肿瘤，
显身卡
