看见一个 Expert Review of Anticancer Therapy。你们前面用依维莫斯,血、肝肾功能还好。下一步是否考虑索拉非尼+依维莫斯。供你参考。
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Currently available feasibility data for possible combination strategies.
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, j% b( @; k p2 J& j. @. zCombination Feasibility according to preliminary data
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; M8 j7 l( K" I) K6 {Bevacizumab + sorafenib Yes, reduced dose $ \# O& ?0 D2 o
Bevacizumab + sunitinib† No
7 H8 A1 C R; u- `" lBevacizumab + temsirolimus Yes
- h& b2 o9 E( P4 v; pBevacizumab + everolimus Yes
8 C) a) T: R* M2 VSorafenib + sunitinib ?
; t, P" |1 U0 n2 f6 T$ x* O9 e5 LSorafenib + temsirolimus Yes, reduced dose 6 L) ?: @" X; |0 C$ k% Z" q9 t, _
Sorafenib + everolimus Yes, reduced dose
6 Y0 f% a& N: X6 ]- BSunitinib + temsirolimus† No - B9 ]1 r- i3 ?5 l- d
Sunitinib + everolimus ?
8 u9 M* N3 L& [+ S% D N* S2 vTemsirolimus + everolimus ? % W/ S% j- t8 \; e& g3 h- m; ^
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& F( s2 z+ \* ]†Led to US FDA warning.4 v% Z0 S3 W3 m. ] }' i* x, y" T
?: As yet unattempted combination.. a( i9 q% Z; m2 V& Y
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