看见一个 Expert Review of Anticancer Therapy。你们前面用依维莫斯,血、肝肾功能还好。下一步是否考虑索拉非尼+依维莫斯。供你参考。# C) u6 m' A1 e/ _& }+ J' `
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Currently available feasibility data for possible combination strategies.
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Combination Feasibility according to preliminary data . N0 y6 B$ g S( F# C
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0 ^, ^5 w% o' jBevacizumab + sorafenib Yes, reduced dose
: F$ `) _3 r* q, OBevacizumab + sunitinib† No / U$ h1 [3 d" r2 \* |) d
Bevacizumab + temsirolimus Yes
+ D0 B$ ]9 g( J% s4 n$ {5 \( D+ rBevacizumab + everolimus Yes
& w* q' a+ e F5 O2 WSorafenib + sunitinib ? 0 I$ q" r" }& k) Q, A8 B
Sorafenib + temsirolimus Yes, reduced dose * Z% [ D! ?& E: \ G! u" |! Z
Sorafenib + everolimus Yes, reduced dose
* G; @, q) f k* j: u5 jSunitinib + temsirolimus† No
8 W0 S" a# G8 j8 F1 fSunitinib + everolimus ?
6 U |9 r5 S' I9 N; NTemsirolimus + everolimus ?
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†Led to US FDA warning.4 ~/ h( G1 r) f1 X& u
?: As yet unattempted combination.' Z( n7 ~! W0 V6 A
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